August 23, 2018  |  Medical News Today  |  Maria Cohut
The endolysosomal system is responsible for ridding the body of waste material from cells. Like so many of our biological functions, this system becomes less efficient as we get older.

Alzheimer’s is related to age. The plaques and tangles that are hallmarks of the disease are cellular waste that remains in the brain. Scientists at the South Australian Health and Medical Research Institute found a likely connection between this faltering waste removal system and AD.

Dr. Tim Sargeant, one of the papers authors said of the findings;  “This research is an important step in understanding how dysfunction in the brain’s recycling machinery may cause Alzheimer’s disease, and may be the key to unlocking new drug targets, or treatment strategies.”
The original study was reported in the journal Brain. (Abstract)

A connection between cancer and Alzheimer’s disease?

August 22, 2018  |  Science Daily  |  University of Texas
Cellular senescence is a survival mechanism that allows certain stressed cells to survive, but these cells then act abnormally. They become toxic, killing surrounding cells. This stress is involved with cancer.

Researchers at UT Health San Antonio found that these  senescent cells are also associated with the tau tangles found in Alzheimer’s brains. Treating old mice with a  drug combination that included a chemotherapy drug used to treat leukemia, this team of investigators found a marked decrease in tau tangles.

Team leader, Dr. Miranda Orr said of their research, “After clearing the senescent cells, we saw improvements in brain structure and function… The treatment seems to have stopped the disease in its tracks.”

Read a  summary of this study.

Biomarkers and early diagnosis

A little late to the party, the headline on a recent article in the The Northeast Mississippi Daily Journal reads, “Alzheimer’s starts years before symptoms show”. It is good to remind us, though, of the importance of early diagnosis, and the importance of finding accurate, non-invasive diagnostic tools. I found two related reports this week.

August 23, 2018  |  JAMA  |  Eye exam Alzheimer’s diagnosis
Conclusions and Relevance  This study suggests that cognitively healthy individuals with preclinical AD have retinal microvascular abnormalities in addition to architectural alterations and that these changes occur at earlier stages of AD than has previously been demonstrated. Longitudinal studies in larger cohorts are needed to determine whether this finding has value in identifying preclinical AD.

August 23, 2018  |  Science Daily  |  Autobiographical memory tested for early Alzheimer’s detection
Summary: A psychologist found that carriers of a gene variant that increases the risk for Alzheimer’s disease have greater difficulty describing detailed memories of past events. The goal of his research is to help detect Alzheimer’s disease-related brain changes before they begin to have an obvious effect on cognition and memory.